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A Canonical 3-D P53 Network Model that Determines Cell Fate by Counting Pulses 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (ISTANBUL UNIV, FAC ENGINEERING, 2018)
From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. Each of these modes are ...
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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
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Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
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Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2020)
Double-strand break-induced (DSB) cells send signal that induces DSBs in neighbour cells, resulting in the interaction among cells sharing the same medium. Since p53 network gives oscillatory response to DSBs, such interaction ...
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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (IET Systems Biology, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
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Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (IET Systems Biology, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
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A 2-dimensional model of polynomial type for oscillatory ATM-Wipl dynamics in p53 network 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (2017 10th International Conference on Electrical and Electronics Engineering, ELECO 2017, 2018)
Under gamma irradiation, p53 gene regulatory network is able to exhibit three different modes, namely low state, oscillations, and high state. There are experimental studies demonstrating that oscillatory behaviour of p53 ...
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A canonical 3-D P53 network model that determines cell fate by counting pulses 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (Istanbul University - Journal of Electrical and Electronics Engineering, 2018)
From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. Each of these modes are ...
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Discriminant-based bistability analysis of a TMG-induced lac operon model supported with boundedness and local stability results 

Avcu, N.; Demir, G.K.; Pekergin, F.; Alyuruk, H.; Cavas, L.; Guzelis, C. (Turkish Journal of Electrical Engineering and Computer Sciences, 2016)
This paper presents the results of a theoretical and numerical study on the analysis of bistable behavior of the most studied gene regulatory network, the lac operon, in terms of the model parameters. The boundedness of ...
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A 2-Dimensional Model of Polynomial Type for Oscillatory ATM-Wip1 Dynamics in p53 Network 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (IEEE, 2017)
Under gamma irradiation, p53 gene regulatory network is able to exhibit three different modes, namely low state, oscillations, and high state. There are experimental studies demonstrating that oscillatory behaviour of p53 ...
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Demir, G.K. (12)
Guzelis, C. (12)
Demirkiran, G. (11)Alyuruk, H. (1)Avcu, N. (1)Cavas, L. (1)Pekergin, F. (1)Date Issued2018 (7)2017 (2)2020 (2)2016 (1)Has File(s)No (12)

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