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A Canonical 3-D P53 Network Model that Determines Cell Fate by Counting Pulses 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (ISTANBUL UNIV, FAC ENGINEERING, 2018)
From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. Each of these modes are ...
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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
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Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
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Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2020)
Double-strand break-induced (DSB) cells send signal that induces DSBs in neighbour cells, resulting in the interaction among cells sharing the same medium. Since p53 network gives oscillatory response to DSBs, such interaction ...
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Investigation of Chaotic Mixing Performance on Characteristic Properties of Cake Batter 

Uzel, R.A.; Izmir, T.T.; Demirkiran, G.; Sahin, S.; Guzelis, C. (IEEE, 2019)
Chaotification is the process of making an originally non chaotic system being chaotic by applying a suitable control input. The aim of the study was to create a chaotic mixing mechanism using a kitchen type mixer and to ...
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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (IET Systems Biology, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
Thumbnail

Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (IET Systems Biology, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
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Effect of chaotic mixing on the rheological characterization of mayonnaise 

Genc, S.; Izmir, T.T.; Uzel, R.A.; Demirkiran, G.; Sahin, S.; Guzelis, C. (2017 10th International Conference on Electrical and Electronics Engineering, ELECO 2017, 2018)
In this study, a new mixing method for mayonnaise was developed. A chaotic hand mixer was designed. The speed of the mixer rotor was chaotically changed with the proposed method. Performance of the mixed mayonnaise was ...
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A 2-dimensional model of polynomial type for oscillatory ATM-Wipl dynamics in p53 network 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (2017 10th International Conference on Electrical and Electronics Engineering, ELECO 2017, 2018)
Under gamma irradiation, p53 gene regulatory network is able to exhibit three different modes, namely low state, oscillations, and high state. There are experimental studies demonstrating that oscillatory behaviour of p53 ...
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A canonical 3-D P53 network model that determines cell fate by counting pulses 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (Istanbul University - Journal of Electrical and Electronics Engineering, 2018)
From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. Each of these modes are ...
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Demirkiran, G. (16)
Guzelis, C. (16)
Demir, G.K. (11)Sahin, S. (3)Uzel, R.A. (3)Izmir, T.T. (2)Biyik, E. (1)Bulut, O. (1)Genc, S. (1)Kahraman, A. (1)... View MoreDate Issued2018 (9)2019 (3)2017 (2)2020 (2)Has File(s)
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