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A Canonical 3-D P53 Network Model that Determines Cell Fate by Counting Pulses 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (ISTANBUL UNIV, FAC ENGINEERING, 2018)
From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. Each of these modes are ...
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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
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Aggregation for Computing Multi-Modal Stationary Distributions in 1-D Gene Regulatory Networks 

Avcu, N.; Pekergin, N.; Pekergin, F.; Guzelis, C. (IEEE COMPUTER SOC, 2018)
This paper proposes aggregation-based, three-stage algorithms to overcome the numerical problems encountered in computing stationary distributions and mean first passage times for multi-modal birth-death processes of large ...
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Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
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Data Dependent Stable Robust Adaptive Controller Design for Altitude Control of Quadrotor Model 

Soydemir, M.U.; Alkus, I.; Bulucu, P.; Kocaoglu, A.; Guzelis, C. (IEEE, 2018)
This paper presents Nonlinear Auto Regressive Moving Average (NARMA) based stable robust adaptive controller design. Both the plant and the closed-loop controller systems are modelled by the proposed NARMA based input-output ...
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Conditional Weighted Ensemble of Transferred Models for Camera Based Onboard Pedestrian Detection in Railway Driver Support Systems 

Toprak, T.; Belenlioglu, B.; Aydin, B.; Guzelis, C.; Selver, M.A. (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2020)
Pedestrian Detection (PD) is one of the most studied issues of driver assistance systems. Although a tremendous effort is already given to create datasets and to develop classifiers for cars, studies about railway systems ...
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Learning Stable Robust Adaptive NARMA Controller for UAV and Its Application to Twin Rotor MIMO Systems 

Bulucu, P.; Soydemir, M.U.; Sahin, S.; Kocaoglu, A.; Guzelis, C. (SPRINGER, 2020)
This study presents a nonlinear auto-regressive moving average (NARMA) based online learning controller algorithm providing adaptability, robustness and the closed loop system stability. Both the controller and the plant ...
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Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon 

Demirkiran, G.; Demir, G.K.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2020)
Double-strand break-induced (DSB) cells send signal that induces DSBs in neighbour cells, resulting in the interaction among cells sharing the same medium. Since p53 network gives oscillatory response to DSBs, such interaction ...
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Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method 

Avcu, N.; Guzelis, C. (INST ENGINEERING TECHNOLOGY-IET, 2019)
Most of the biological systems including gene regulatory networks can be described well by ordinary differential equation models with rational non-linearities. These models are derived either based on the reaction kinetics ...
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Design of microcontroller-based decentralized controller board to drive chiller systems using PID and fuzzy logic algorithms 

Isler, Y.; Sahin, S.; Ekren, O.; Guzelis, C. (SAGE PUBLICATIONS LTD, 2020)
This study deals with designing a decentralized multi-input multi-output controller board based on a low-cost microcontroller, which drives both parts of variable-speed scroll compressor and electronic-type expansion valve ...
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Guzelis, C. (52)
Demirkiran, G. (16)Sahin, S. (13)Demir, G.K. (12)Bulucu, P. (8)Kocaoglu, A. (8)Soydemir, M.U. (8)Avcu, N. (6)Nakip, M. (6)Pekergin, F. (4)... View MoreDate Issued2019 (16)2018 (13)2020 (10)2016 (8)2017 (5)Has File(s)
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