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Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics
(IET Systems Biology, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model
(IET Systems Biology, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method
(IET Systems Biology, 2019)
Most of the biological systems including gene regulatory networks can be described well by ordinary differential equation models with rational non-linearities. These models are derived either based on the reaction kinetics ...