Ara
Toplam kayıt 4, listelenen: 1-4
Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics
(IET Systems Biology, 2018)
p53 network, which is responsible for DNA damage response of cells, exhibits three distinct qualitative behaviours; low state, oscillation and high state, which are associated with normal cell cycle progression, cell cycle ...
Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model
(IET Systems Biology, 2018)
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, ...
Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method
(IET Systems Biology, 2019)
Most of the biological systems including gene regulatory networks can be described well by ordinary differential equation models with rational non-linearities. These models are derived either based on the reaction kinetics ...
Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon
(IET Systems Biology, 2020)
Double-strand break-induced (DSB) cells send signal that induces DSBs in neighbour cells, resulting in the interaction among cells sharing the same medium. Since p53 network gives oscillatory response to DSBs, such interaction ...